Article
Environment-independent distribution of mutational effects emerges from microscopic epistasis.
Science (New York, N.Y.) - 4 Oct 2024
Ardell Sarah M, Martsul Alena, Johnson Milo S, Kryazhimskiy Sergey
Abstract excerpt
Predicting how new mutations alter phenotypes is difficult because mutational effects vary across genotypes and environments. Recently discovered global epistasis, in which the fitness effects of mutations scale with the fitness of the background genotype, can improve predictions, but how the environment modulates this scaling is unknown. We measured the fitness effects of ~100 insertion mutations in 42 strains...
Topics
- Epistasis, Genetic
- Saccharomyces cerevisiae
- Genetic Fitness
- Phenotype
- Gene-Environment Interaction
- Genotype
- INDEL Mutation
- Mutation
- Environment