Can Omega-3 polyunsaturated fatty acids improve bone mineral density?: Evidence from a Mendelian randomization study.

Abstract excerpt

Previous studies have reported controversial associations between n-3 polyunsaturated fatty acids (n-3 PUFA) and bone mineral density (BMD). To clarify whether a causal relationship exists, this study employed a 2-sample Mendelian randomization analysis using single-nucleotide polymorphisms significantly associated with n-3 PUFA as instrumental variables; data for both exposure (n-3 PUFA) and outcome (BMD) were...

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