Article
Causal relationships between body mass index, low-density lipoprotein and bone mineral density: Univariable and multivariable Mendelian randomization.
PloS one - 1 Jan 2024
Wu Yuxiang, Ma Weiwei, Cheng Zhenda, Zhang Qiwei, Li Zhaodong, Weng Punan, Li Bushuang, Huang Zhiqiang, Fu Changlong
Abstract excerpt
SUMMARY: Utilizing the Mendelian randomization technique, this research clarifies the putative causal relationship between body mass index (BMI) andbone mineral density (BMD), and the mediating role of low-density lipoprotein (LDL). The implications of these findings present promising opportunities for enhancing our understanding of complex bone-related characteristics and disorders, offering potential directions...
Topics
- Humans
- Bone Density
- Body Mass Index
- Mendelian Randomization Analysis
- Lipoproteins, LDL
- Genome-Wide Association Study
- Polymorphism, Single Nucleotide
- Female