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Article

PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly.

Current osteoporosis reports - 10 Apr 2026

Li Siwen, Trajanoska Katerina

Abstract excerpt

PURPOSE OF REVIEW: While GWAS has identified many loci associated with bone mineral density (BMD), translating these findings into functional insights and treatments remains challenging. Post-GWAS methods such as Transcriptome-Wide Association Study (TWAS), Phenome-Wide Association Study (PheWAS), and Mendelian Randomization (MR) provide complementary strategies to prioritize genes and causal risk factors. This...

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Identifiers

PMID: 41957283
DOI: 10.1007/s11914-026-00962-5
PMCID: PMC13065573

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