Article
Absence of causal association between Vitamin D and bone mineral density across the lifespan: a Mendelian randomization study.
Scientific reports - 21 Jun 2022
Tang Yanchao, Wei Feng, Yu Miao, Zhou Hua, Wang Yongqiang, Cui Zhiyong, Liu Xiaoguang
Abstract excerpt
Vitamin D deficiency is a candidate risk factor for osteoporosis, characterized by decreased bone mineral density (BMD). We performed this two-sample Mendelian randomization (MR) analysis to investigate the causal effect of vitamin D on BMD. We extracted 143 single-nucleotide polymorphisms from a recent GWAS on 417,580 participants of European ancestry as instrumental variables, and used summary statistics for...
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