Article
Bidirectional genetic overlap between mood swings and irritable bowel syndrome.
Psychiatric genetics - 1 Dec 2025
Luo Qinghua, Wang Jiawen, An Mingwei, Zhang Leichang, Wang Chen
Abstract excerpt
BACKGROUND: Mood swings and irritable bowel syndrome (IBS) are closely related. However, the reason for the clinical concurrence of this phenomenon is unknown, and maybe it is because the two share genetic underpinnings. METHODS: Genome-wide association studies (GWAS) of mood swings and IBS data were used for the study. Genetic correlation was assessed using the linkage disequilibrium score regression (LDSC),...
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