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Article

Distribution of allele frequencies and effect sizes and their interrelationships for common genetic susceptibility variants.

Proceedings of the National Academy of Sciences of the United States of America - 1 Nov 2011

Park Ju-Hyun, Gail Mitchell H, Weinberg Clarice R, Carroll Raymond J, Chung Charles C, Wang Zhaoming, Chanock Stephen J, Fraumeni Joseph F, Chatterjee Nilanjan

Abstract excerpt

Recent discoveries of hundreds of common susceptibility SNPs from genome-wide association studies provide a unique opportunity to examine population genetic models for complex traits. In this report, we investigate distributions of various population genetic parameters and their interrelationships using estimates of allele frequencies and effect-size parameters for about 400 susceptibility SNPs across a spectrum...

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PMID: 22003128
DOI: 10.1073/pnas.1114759108
PMCID: PMC3207674

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