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Genetic insights of waist-to-height ratio on the risk of steatotic and advanced liver diseases: genome-wide association study and polygenic risk score-based analyses.

Human genomics - 3 Nov 2025

Chen Haotian, Liu Zhengye, Du Hanze, Wan Ziqi, Bai Xiaoyin, Mi Jiarui

Abstract excerpt

BACKGROUND: The waist-to-height ratio (WHtR) is a simple and effective indicator to measure central obesity. However, the genetic basis and clinical implications of WHtR in relation to steatotic and advanced liver diseases remain largely unexplored. METHODS: We performed a genome-wide association study (GWAS) in European individuals from the UK Biobank to identify genetic variants associated with WHtR, followed...

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Identifiers

PMID: 41184917
DOI: 10.1186/s40246-025-00832-8
PMCID: PMC12581380

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CCND2
VEGFB

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