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Article

Deep Sequencing of mHVRs for Trypanosoma cruzi Genotyping.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2026

Díaz Anahí G, Rusman Fanny, Tomasini Nicolás

Abstract excerpt

Trypanosoma cruzi exhibits remarkable genetic diversity, with six main evolutionary lineages or discrete typing units (DTUs), namely TcI to TcVI. Identifying these DTUs is essential for understanding the role of genetics in the biology, epidemiology, and clinical implications of Chagas disease. However, molecular methods proposed to identify T. cruzi lineages in clinical samples exhibit sensitivity limitations...

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PMID: 41182613
DOI: 10.1007/978-1-0716-4848-3_7

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