Revisiting gene typing and phylogeny of Trypanosoma cruzi reference strains: Comparison of the relevance of mitochondrial DNA, single-copy nuclear DNA, and the intergenic region of mini-exon gene.

Abstract excerpt

Chagas disease is a widespread neglected disease in Latin America. Trypanosoma cruzi, the causative agent of the disease, is currently subdivided into six DTUs (discrete typing units) named TcI-TcVI, and although no clear association has been found between parasite genetics and different clinical outcomes of the disease or different transmission cycles, genetic characterization of T. cruzi strains remains crucial...

Topics

• Humans
• Trypanosoma cruzi
• Phylogeny
• DNA, Mitochondrial
• DNA, Intergenic
• Genotype
• Chagas Disease
• Exons
• Genetic Variation
• DNA, Protozoan