Article
Multilocus sequence typing (MLST) for lineage assignment and high resolution diversity studies in Trypanosoma cruzi.
PLoS neglected tropical diseases - 1 Jun 2011
Yeo Matthew, Mauricio Isabel L, Messenger Louisa A, Lewis Michael D, Llewellyn Martin S, Acosta Nidia, Bhattacharyya Tapan, Diosque Patricio, Carrasco Hernan J, Miles Michael A
Abstract excerpt
BACKGROUND: Multilocus sequence typing (MLST) is a powerful and highly discriminatory method for analysing pathogen population structure and epidemiology. Trypanosoma cruzi, the protozoan agent of American trypanosomiasis (Chagas disease), has remarkable genetic and ecological diversity. A standardised MLST protocol that is suitable for assignment of T. cruzi isolates to genetic lineage and for higher resolution...
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