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Deciphering Trypanosoma lainsoni kDNA minicircles: insights into genetic diversity, mRNA editing, and molecular diagnosis.

Parasite (Paris, France) - 1 Jan 2026

Aguirre Juan José, Floridia-Yapur Noelia, Rusman Fanny, Hodi Soledad, Ponce Tatiana, Diaz Anahí Guadalupe, Greif Gonzalo, Berná Luisa, Robello Carlos, Diosque Patricio, Tomasini Nicolás

Abstract excerpt

The mitochondrial genome of kinetoplastids, organized in a unique DNA net called the kinetoplast, presents significant complexity compared to other eukaryotic mitochondrial genomes. Minicircles, which constitute over 90% of the kinetoplast mass, are essential for the post-transcriptional editing of maxicircle transcripts. This study focuses on Trypanosoma lainsoni, a trypanosomatid first discovered in northern...

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PMID: 42234832
DOI: 10.1051/parasite/2026034
PMCID: PMC13233029

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