Article
Deciphering Trypanosoma lainsoni kDNA minicircles: insights into genetic diversity, mRNA editing, and molecular diagnosis.
Parasite (Paris, France) - 1 Jan 2026
Aguirre Juan José, Floridia-Yapur Noelia, Rusman Fanny, Hodi Soledad, Ponce Tatiana, Diaz Anahí Guadalupe, Greif Gonzalo, Berná Luisa, Robello Carlos, Diosque Patricio, Tomasini Nicolás
Abstract excerpt
The mitochondrial genome of kinetoplastids, organized in a unique DNA net called the kinetoplast, presents significant complexity compared to other eukaryotic mitochondrial genomes. Minicircles, which constitute over 90% of the kinetoplast mass, are essential for the post-transcriptional editing of maxicircle transcripts. This study focuses on Trypanosoma lainsoni, a trypanosomatid first discovered in northern...
Topics
- DNA, Kinetoplast
- Trypanosoma
- Genetic Variation
- RNA Editing
- Trypanosomiasis
- Argentina
- DNA, Protozoan
- Base Sequence
- Animals
- Polymerase Chain Reaction
- RNA, Messenger
- RNA, Guide, Kinetoplastida
- Humans