Prognostic Relevance of Inflammatory Subphenotypes in Immunocompromised Patients With Sepsis.

doi:10.1097/CCM.0000000000006920

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Article

Prognostic Relevance of Inflammatory Subphenotypes in Immunocompromised Patients With Sepsis.

Critical care medicine - 1 Dec 2025

Weingart Melanie F, Willmore Andrew, Zhuo Hanjing, Magee Liam, Chao Olivia, Lin Chelsea, Schmiege Emma, Hariharan Taarini, Chak Suzanna, Bardillon Kim, Lee Deanna, Leroux Carolyn, Obeidalla Sarah N, Kerchberger V Eric, Sullivan Kathryn, Langelier Charles, Hendrickson Carolyn M, Kangelaris Kirsten N, Sarma Aartik, Evrard Bruno, Alipanah-Lechner Narges, Sinha Pratik, Matthay Michael A, Ware Lorraine B, Calfee Carolyn S

Abstract excerpt

OBJECTIVES: Hyperinflammatory and hypoinflammatory molecular subphenotypes in sepsis and acute respiratory distress syndrome have divergent mortality and treatment responses in secondary analyses of randomized controlled trials. However, the prevalence of immunocompromise is low in these populations, and how preexisting immunocompromise contributes to subphenotypes is unknown. We studied two observational sepsis...

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PMID: 41150892
DOI: 10.1097/CCM.0000000000006920
PMCID: PMC12912362

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