Peripheral immune phenotyping identifies an immunosuppressed sepsis endotype with potential relevance for immune stratification.

doi:10.3389/fimmu.2026.1939205

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Article

Peripheral immune phenotyping identifies an immunosuppressed sepsis endotype with potential relevance for immune stratification.

Frontiers in immunology - 1 Jan 2026

Luo Rong, Xie Yixia, Deng Xiaofan, Hong Chengying, Liang Yingying, Xia Jinquan, Zhang Da, Liu Jingjin, Chen Chunbo, Chen Huaisheng

Abstract excerpt

Background: Sepsis is characterized by profound immune dysregulation, yet the biological significance and clinical application of peripheral immune phenotyping in sepsis remain incompletely defined. This study aimed to define internally identified immune phenotypes in sepsis and evaluate their prognostic and translational relevance. Methods: In this single-centre retrospective cohort study, 374 adult patients...

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Topics

Humans
Sepsis
Female
Male
Immunophenotyping
Retrospective Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Middle Aged

Prognosis

Aged

Biomarkers

Phenotype

Immunocompromised Host

HLA-DR Antigens

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PMID: 42761118
DOI: 10.3389/fimmu.2026.1939205
PMCID: PMC13585658

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