Article
Pediatric therapy-related hematologic neoplasms show enrichment for KMT2A rearrangement and lymphoblastic phenotype.
Leukemia & lymphoma - 1 Dec 2024
Kovach Alexandra E, Komova Daria, Itov Albert, Gaskova Maria, Kalinina Irina, Voronin Kirill, Rumiantseva Yulia, Karachunskii Alexander, Maschan Michael, Maschan Alexey, Novichkova Galina, Olshanskaya Yulia, Bhojwani Deepa, Raca Gordana, Zerkalenkova Elena
Abstract excerpt
In children, therapy-related hematologic neoplasms (t-HN) are uncommon. Many are driven by genetic events independent of clonal hematopoiesis. We sought to understand the clinical and genetic factors of pediatric t-HN in a large independent cohort. Fifty-six t-HN were retrospectively identified. Chromosome microarray, next-generation and/or RNA sequencing were performed. Patients had primary hematologic, solid,...
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