Article
Estrogen and BRCA1 deficiency synergistically induce breast cancer mutation-related DNA damage.
Biochemical and biophysical research communications - 12 Jul 2022
Chen Jiahao, Liu Jingxin, Zeng Pengguihang, Zhao Cai, Liu Xinyi, Sun Jun, Wang Jia, Fang Peihang, Chen Wenjie, Ding Junjun
Abstract excerpt
Estrogen (E2) is crucial for the development of breast cancer caused by BRCA1 mutation, and can increase the DNA damage in BRCA1-deficient cells. However, the mechanisms through which BRCA1 deficiency and E2 synergistically induce DNA damage remains unclear. In this study, we analyzed the distribution of DNA damage in E2-treated BRCA1-deficient cells. We detected DNA lesions in the vicinity of genes that are...
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