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Article

Variability in intrinsic drug tolerance in Mycobacterium tuberculosis corresponds with phylogenetic lineage.

Antimicrobial agents and chemotherapy - 10 Dec 2025

March Valerie F A, Zwyer Michaela, Loiseau Chloé, Brites Daniela, Goig Galo A, Bouaouina Selim, Doetsch Anna, Reinhard Miriam, Kalkan Sevda, Gagneux Sebastien, Borrell Sonia

Abstract excerpt

Drug tolerance allows bacteria to survive extended exposure to bactericidal drugs and is thought to play a role in drug resistance evolution. In Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), multidrug-resistant TB outbreaks are frequently caused by strains belonging to two phylogenetic lineages of the human-adapted strains of the Mtb complex, namely, lineages (L) 2 and L4. We...

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Identifiers

PMID: 41118320
DOI: 10.1128/aac.00996-25
PMCID: PMC12691649

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