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Article

Reinterpreting the action of ATP analogs on K(ATP) channels.

The Journal of biological chemistry - 28 Jun 2013

Ortiz David, Gossack Lindsay, Quast Ulrich, Bryan Joseph

Abstract excerpt

Neuroendocrine-type K(ATP) channels, (SUR1/Kir6.2)4, couple the transmembrane flux of K(+), and thus membrane potential, with cellular metabolism in various cell types including insulin-secreting β-cells. Mutant channels with reduced activity are a cause of congenital hyperinsulinism, whereas hyperactive channels are a cause of neonatal diabetes. A current regulatory model proposes that ATP hydrolysis is required...

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PMID: 23665564
DOI: 10.1074/jbc.M113.476887
PMCID: PMC3696665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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