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Clonal hematopoiesis of indeterminate potential: contribution to disease and promising interventions.

Molecular and cellular biochemistry - 1 Jul 2025

Li Chongjie, Zhang Chunxiang, Li Xiuying

Abstract excerpt

In clonal hematopoiesis of indeterminate potential (CHIP), subpopulations of blood cells carrying somatic mutations expand as the individual ages, and this expansion may elevate risk of blood cancers as well as cardiovascular disease. Individuals at higher risk of CHIP and therefore of CHIP-associated disease can be identified through mutational profiling, and the apparently central role of inflammation in...

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PMID: 40140229
DOI: 10.1007/s11010-025-05261-8

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