Article
Genetic Ancestry Inference for Pharmacogenomics.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2022
Jordan I King, Sharma Shivam, Nagar Shashwat Deepali, Valderrama-Aguirre Augusto, Mariño-Ramírez Leonardo
Abstract excerpt
Genetic ancestry inference can be used to stratify patient cohorts and to model pharmacogenomic variation within and between populations. We provide a detailed guide to genetic ancestry inference using genome-wide genetic variant datasets, with an emphasis on two widely used techniques: principal components analysis (PCA) and ADMIXTURE analysis. PCA can be used for patient stratification and categorical ancestry...
Topics
- Genetic Techniques
- Genetics, Population
- Humans
- Pharmacogenetics
- Polymorphism, Single Nucleotide
- Population Groups
- Principal Component Analysis