Article
Robust inference of population structure for ancestry prediction and correction of stratification in the presence of relatedness.
Genetic epidemiology - 1 May 2015
Conomos Matthew P, Miller Michael B, Thornton Timothy A
Abstract excerpt
Population structure inference with genetic data has been motivated by a variety of applications in population genetics and genetic association studies. Several approaches have been proposed for the identification of genetic ancestry differences in samples where study participants are assumed to be unrelated, including principal components analysis (PCA), multidimensional scaling (MDS), and model-based methods...
Topics
- Algorithms
- Chromosome Mapping
- Computer Simulation
- Genetic Association Studies
- Genetics, Population
- HapMap Project
- Humans
- Models, Genetic
- Polymorphism, Single Nucleotide
- Population Groups
- Principal Component Analysis