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Article

Unique Genetic and Epigenetic Alterations in Glioblastoma Long-Term Survivors: Insights From Two Clinical Cases.

Journal of cellular and molecular medicine - 1 Oct 2025

Anghileri Elena, Miele Evelina, Patrizi Sara, Barresi Sabina, Lazzarini Elisabetta, Maddaloni Luisa, Patanè Monica, Pedace Lucia, Paterra Rosina, Silvani Antonio, Locatelli Franco, Indraccolo Stefano, Pollo Bianca

Abstract excerpt

The biological mechanisms driving the long survival in glioblastoma (GBM). Five-year long-term survival (LTS) and 10-year survival very long-term survival (VLTS) remain significantly understudied. Here we molecularly detailed two cases. AR10-046 (VLTS) was affected by a giant cell-GBM, classified as the pedHGG_RTK1a subtype according to the v12.5 Heidelberg brain tumor methylation classifier. Somatic and germline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41085137
DOI: 10.1111/jcmm.70771
PMCID: PMC12519515

Genes

CPM
CPSF6
MDM2
MSH6
PTPRR
RAB3IP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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