Article
Longitudinal analysis of treatment-induced genomic alterations in gliomas.
Genome medicine - 2 Feb 2017
Erson-Omay E Zeynep, Henegariu Octavian, Omay S Bülent, Harmancı Akdes Serin, Youngblood Mark W, Mishra-Gorur Ketu, Li Jie, Özduman Koray, Carrión-Grant Geneive, Clark Victoria E, Çağlar Caner, Bakırcıoğlu Mehmet, Pamir M Necmettin, Tabar Viviane, Vortmeyer Alexander O, Bilguvar Kaya, Yasuno Katsuhito, DeAngelis Lisa M, Baehring Joachim M, Moliterno Jennifer, Günel Murat
Abstract excerpt
BACKGROUND: Glioblastoma multiforme (GBM) constitutes nearly half of all malignant brain tumors and has a median survival of 15 months. The standard treatment for these lesions includes maximal resection, radiotherapy, and chemotherapy; however, individual tumors display immense variability in their response to these approaches. Genomic techniques such as whole-exome sequencing (WES) provide an opportunity to...
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