Article
Molecular Study of Long-Term Survivors of Glioblastoma by Gene-Targeted Next-Generation Sequencing.
Journal of neuropathology and experimental neurology - 1 Aug 2018
Cantero Diana, Rodríguez de Lope Ángel, Moreno de la Presa Raquel, Sepúlveda Juan M, Borrás José M, Castresana Javier S, D'Haene Nicky, García Juan F, Salmon Isabelle, Mollejo Manuela, Rey Juan A, Hernández-Laín Aurelio, Meléndez Bárbara
Abstract excerpt
Glioblastoma (GBM) is the most common malignant adult primary brain tumor. Despite its high lethality, a small proportion of patients have a relatively long overall survival (OS). Here we report a study of a series of 74 GBM samples from 29 long-term survivors ([LTS] OS ≥36 months) and 45 non-LTS. Using next-generation sequencing, we analyzed genetic alterations in the genes most frequently altered in gliomas....
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