Clinicopathologic, molecular and tumor immune microenvironment features of mismatch repair-deficient glioblastomas in Lynch syndrome: a multicenter study of 29 cases with therapeutic implications.

doi:10.1186/s40478-026-02246-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Clinicopathologic, molecular and tumor immune microenvironment features of mismatch repair-deficient glioblastomas in Lynch syndrome: a multicenter study of 29 cases with therapeutic implications.

Acta neuropathologica communications - 5 Mar 2026

Yao Zhi-Gang, Li Xue-Long, Wen Wen-Juan, Lin Xiao-Yan, Zhang Gui-Hui, Sun Yi-Ping, Nie Yi-Cong, Zheng Zhi-Ming, Xu Yu-Qiao, Yang Mu, Yu Tai-Fei, Dong Yin, Hou Yang-Hao, Dang Lin-Lin, Chu Shu-Guang, Li Jia-Mei, Ma Ji-Wei, Wang Zhou, Hua Fang, Wang Xing-Fu, Wang Dai-Zhong, Hu Wan-Ming

Abstract excerpt

Glioblastoma (GBM) is a relatively rare manifestation of Lynch syndrome (LS), and its defining characteristics are not yet fully defined. This study employs an integrated analysis of the clinicopathological, molecular, and tumor immune microenvironment features of LS-GBMs to elucidate its distinct biology and inform diagnostic and therapeutic strategies. We collected GBM samples from 29 LS patients across...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to DNA Mismatch Repair

Share to Germ-Line Mutation

Share to Glioblastoma

Share to MutS Homolog 2 Protein

Share to Tumor Microenvironment

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 41782063
DOI: 10.1186/s40478-026-02246-6
PMCID: PMC12961846

Genes

CD163
EGFR
MLH1
MSH2
MSH6
NF1
PDGFRA
PMS2
SETD2
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Clinicopathologic, molecular and tumor immune microenvironment features of mismatch repair-deficient glioblastomas in Lynch syndrome: a multicenter study of 29 cases with therapeutic implications.PMID 41782063Read ↗

Sporadic and Lynch syndrome-associated mismatch repair-deficient brain tumors.Semantic proximity Read ↗

A Long-term Progression-free Survival with Glioblastoma Patient Harboring MSH6 Pathogenic Germline Mutation: A Case ReportSemantic proximity Read ↗

Pembrolizumab alters the tumor immune landscape in a patient with dMMR glioblastomaSemantic proximity Read ↗

High tumor mutational burden and T-cell activation are associated with long-term response to anti-PD1 therapy in Lynch syndrome recurrent glioblastoma patient.Semantic proximity Read ↗

New Insights into Lynch Syndrome: A Narrative Review.Semantic proximity Read ↗

Incidence and molecular characteristics of deficient mismatch repair conditions across nine different tumors and identification of germline variants involved in Lynch-like syndromeSemantic proximity Read ↗

"De novo replication repair deficient glioblastoma, IDH-wildtype" is a distinct glioblastoma subtype in adults that may benefit from immune checkpoint blockade.Semantic proximity Read ↗

Glioblastomas, astrocytomas and oligodendrogliomas linked to Lynch syndromeSemantic proximity Read ↗

Mismatch repair deficiency testing in clinical practiceSemantic proximity Read ↗

The distinct clinical trajectory, metastatic sites, and immunobiology of microsatellite-instability-high cancersSemantic proximity Read ↗

Mutational signature profiling classifies subtypes of clinically different mismatch repair deficient tumors with a differential immunogenic response potentialSemantic proximity Read ↗

An unusual phenotype occurs in 15% of mismatch repair-deficient tumors and is associated with non-colorectal cancers and genetic syndromes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.