Article
Somatic copy number alterations are associated with EGFR amplification and shortened survival in patients with primary glioblastoma.
Neoplasia (New York, N.Y.) - 1 Jan 2020
Muñoz-Hidalgo Lisandra, San-Miguel Teresa, Megías Javier, Monleón Daniel, Navarro Lara, Roldán Pedro, Cerdá-Nicolás Miguel, López-Ginés Concha
Abstract excerpt
Glioblastoma (GBM) is the most common malignant primary tumor of the central nervous system. With no effective therapy, the prognosis for patients is terrible poor. It is highly heterogeneous and EGFR amplification is its most frequent molecular alteration. In this light, we aimed to examine the genetic heterogeneity of GBM and to correlate it with the clinical characteristics of the patients. For that purpose,...
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