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Article

Interplay of host and viral genetic variations in modulating antibody responses to genotype 3a hepatitis C virus: Implications for vaccine design.

Cell reports - 28 Oct 2025

Wang Zhiqing, Humphreys Isla, Quistrebert Jocelyn, Chai Haiting, Stass Robert, Dhir Josh, Nisioi Alexandru, Radford Paul, Ball Jonathan K, Irving William L, Bowden Thomas A, Klenerman Paul, Barnes Eleanor, McKeating Jane A, Tarr Alexander W, Ansari M Azim

Abstract excerpt

Hepatitis C virus (HCV) exhibits significant genetic diversity and is a cause of severe liver complications. The viral envelope glycoproteins E1 and E2, key targets for neutralizing antibodies, are highly variable. To understand how host and viral genetic factors modulate antibody responses, we analyze genetic and antibody binding and neutralization data from 54 patients infected with HCV genotype 3a. We find...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41076628
DOI: 10.1016/j.celrep.2025.116418
PMCID: PMC7618651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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