Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.

doi:10.1016/j.immuni.2021.12.003

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.

Immunity - 8 Feb 2022

Weber Timm, Potthoff Julian, Bizu Sven, Labuhn Maurice, Dold Leona, Schoofs Till, Horning Marcel, Ercanoglu Meryem S, Kreer Christoph, Gieselmann Lutz, Vanshylla Kanika, Langhans Bettina, Janicki Hanna, Ströh Luisa J, Knops Elena, Nierhoff Dirk, Spengler Ulrich, Kaiser Rolf, Bjorkman Pamela J, Krey Thomas, Bankwitz Dorothea, Pfeifer Nico, Pietschmann Thomas, Flyak Andrew I, Klein Florian

Abstract excerpt

The high genetic diversity of hepatitis C virus (HCV) complicates effective vaccine development. We screened a cohort of 435 HCV-infected individuals and found that 2%-5% demonstrated outstanding HCV-neutralizing activity. From four of these patients, we isolated 310 HCV antibodies, including neutralizing antibodies with exceptional breadth and potency. High neutralizing activity was enabled by the use of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Broadly Neutralizing Antibodies

Share to Complementarity Determining Regions

Share to Epitopes

Share to Hepatitis C

Share to Hepatitis C Antibodies

Share to Immunoglobulin Heavy Chains

Share to Viral Envelope Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 34990590
DOI: 10.1016/j.immuni.2021.12.003
PMCID: PMC10089621

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Analysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.PMID 34990590Read ↗

Genetic and structural insights into broad neutralization of hepatitis C virus by human V H 1-69 antibodiesSemantic proximity Read ↗

A Hepatitis C Virus Envelope Polymorphism Confers Resistance to Neutralization by Polyclonal Sera and Broadly Neutralizing Monoclonal AntibodiesSemantic proximity Read ↗

Broadly neutralizing antibodies with few somatic mutations and hepatitis C virus clearanceSemantic proximity Read ↗

Structural and biochemical insights into HCV envelope proteins for germline-targeting vaccinesSemantic proximity Read ↗

AI recognizes convergent somatic hypermutation signatures to allow the discovery of variant-resilient broadly neutralizing antibodiesSemantic proximity Read ↗

Viral evasion and challenges of hepatitis C virus vaccine development.Semantic proximity Read ↗

Distinct mechanisms of antibody-mediated HCV neutralization revealed by nanobody-guided epitope mappingSemantic proximity Read ↗

Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target themSemantic proximity Read ↗

Signatures of VH1-69-derived hepatitis C virus neutralizing antibody precursors defined by binding to envelope glycoproteinsSemantic proximity Read ↗

Junctional and somatic hypermutation-induced CX4C motif is critical for the recognition of a highly conserved epitope on HCV E2 by a human broadly neutralizing antibody.Semantic proximity Read ↗

Affinity maturation to improve human monoclonal antibody neutralization potency and breadth against hepatitis C virus.Semantic proximity Read ↗

Interplay of Host and Viral Genetic Variations in Modulating Antibody Responses to Genotype 3a Hepatitis C Virus: Implications for Vaccine DesignSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.