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Article

Sex-related differences in phenotype and nigro-striatal degeneration of c-rel-/- mouse model of Parkinson's disease.

Biology of sex differences - 10 Oct 2025

Parrella Edoardo, Porrini Vanessa, Gennari Michele Mario, Benarese Marina, Del Gallo Federico, Andrioli Anna, Fritzsch Chiara, Bentivoglio Marina, Fabene Paolo Francesco, Pizzi Marina

Abstract excerpt

BACKGROUND: Sex is an important factor in the development and symptom expression of Parkinson's disease (PD). Risk of developing PD, motor and non-motor symptoms and response to treatment differ between men and women, with women showing lower disease incidence, later onset of motor deficits and generally milder symptoms than men. We previously reported that male mice lacking the NF-κB/c-Rel protein (c-rel-/-...

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PMID: 41074203
DOI: 10.1186/s13293-025-00761-0
PMCID: PMC12512402

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