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Article

The effects of house dust-derived mixtures of organophosphate esters on Leydig cell phenotype, function, and lipidome†.

Biology of reproduction - 16 Dec 2025

Li Zixuan, Wang Xiaotong, Hales Barbara F, Robaire Bernard

Abstract excerpt

Organophosphate esters (OPEs), widely used as flame retardants and plasticizers, are frequently detected in indoor environments and human tissues, raising concerns about their potential endocrine-disrupting effects. In this study, we examined the effects of a household dust-based mixture of OPEs, along with two structural distinct sub-mixtures, on the phenotype, function, and lipidome on MA10 Leydig cells. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41071121
DOI: 10.1093/biolre/ioaf229
PMCID: PMC12706469

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