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Article

Effects of an environmentally relevant mixture of organophosphate esters on the phenotype and function of HepG2 liver cells.

Archives of toxicology - 1 Dec 2025

Yu Dongwei, Hales Barbara F, Robaire Bernard

Abstract excerpt

Organophosphate esters (OPEs), commonly used as flame retardants and plasticizers, are ubiquitous environmental contaminants, with high concentrations found in indoor house dust. Previously, we have reported that individual OPEs have adverse effects on HepG2 liver cells. However, real-world exposure involves mixtures of OPEs. In this study, we investigated the effects of an environmentally relevant mixture of...

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PMID: 40897858
DOI: 10.1007/s00204-025-04173-2

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TFEB
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