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Article

The Organophosphate Esters Used as Flame Retardants and Plasticizers Affect H295R Adrenal Cell Phenotypes and Functions.

Endocrinology - 1 Aug 2023

Li Zixuan, Robaire Bernard, Hales Barbara F

Abstract excerpt

Adverse effects associated with exposure to brominated flame retardants have led to regulations for their use and their replacement with organophosphate esters (OPEs). However, little is known about the impact of OPEs on the adrenal, a vital endocrine gland. Here, we used a high-content screening approach to elucidate the effects of OPEs on H295R human adrenal cell phenotypic endpoints and function. The effects...

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PMID: 37522340
DOI: 10.1210/endocr/bqad119
PMCID: PMC10424175

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