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Article

Lipophilic Chemical Accumulation, a Systems Level Driver of Chronic Disease. An Integrated Multi-Omics and Toxicokinetic Framework

2026-02-17

Abstract excerpt

<h4>Background: </h4> Lipophilic environmental contaminants—including persistent organic pollutants (POPs), PFAS, PCBs, and PAHs - exert a long-term biological influence that cannot be explained by acute toxicity alone. Their extreme hydrophobicity drives high-affinity sequestration within lipid-rich tissues, such as adipose depots, myelin sheaths, and endocrine glands, creating "internal reservoirs" with biologic...

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Literature Corpus work
46e7264f-d528-5329-b0bb-9588ed8da825
DOI
10.20944/preprints202602.1261.v1
Open publication

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Lipophilic Chemical Accumulation, a Systems Level Driver of Chronic Disease. An Integrated Multi-Omics and Toxicokinetic FrameworkDOI 10.20944/preprints202602.1261.v1
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