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Article

House dust-derived mixtures of organophosphate esters alter the phenotype, function, transcriptome, and lipidome of KGN human ovarian granulosa cells.

Toxicological sciences : an official journal of the Society of Toxicology - 26 Jun 2024

Wang Xiaotong, Rowan-Carroll Andrea, Meier Matthew J, Yauk Carole L, Wade Michael G, Robaire Bernard, Hales Barbara F

Abstract excerpt

Organophosphate esters (OPEs), used as flame retardants and plasticizers, are present ubiquitously in the environment. Previous studies suggest that exposure to OPEs is detrimental to female fertility in humans. However, no experimental information is available on the effects of OPE mixtures on ovarian granulosa cells, which play essential roles in female reproduction. We used high-content imaging to investigate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38603619
DOI: 10.1093/toxsci/kfae052
PMCID: PMC11199920

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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