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Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

22 Sept 2023

Abstract excerpt

Introduction: Phthalates are a class of endocrine-disrupting chemicals that have been shown to negatively correlate with thyroid hormone serum levels in humans and to cause a state of hyperactivity in the thyroid. However, their mechanism of action is not well described at the molecular level. Methods: We analyzed the response of mouse thyroid organoids to the exposure to a biologically relevant dose range of the...

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PMID: 37810885
DOI: 10.3389/fendo.2023.1200211

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