Back to the wildtype: SARS-CoV-2 evolution in critically ill patients with severe lung failure.

doi:10.1007/s15010-025-02650-5

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Back to the wildtype: SARS-CoV-2 evolution in critically ill patients with severe lung failure.

Infection - 1 Feb 2026

Kraft Tanja, Magnus Clara L, Hiergeist Andreas, Wenzel Jürgen J, Schuster Philipp, Vogel Matthias, Hanses Frank, Dienemann Thomas, Schneckenpointner Roland, Lubnow Matthias, Müller Thomas, Lunz Dirk, Hitzenbichler Florian, Schmid Stephan, Müller Martina, Haehnel Viola, Brosig Andreas-Michael, Offner Robert, Poeck Hendrik, Graf Bernhard, Gessner André, Salzberger Bernd, Wiest Clemens, Schmidt Barbara

Abstract excerpt

OBJECTIVE: To investigate intra-host evolution of SARS-CoV-2 in critically ill patients with severe lung failure. METHODS: Between November 2020 to December 2022, respiratory samples were collected from 41 mechanically ventilated patients at the intensive care unit of University Hospital Regensburg, Germany, including 16 on extracorporeal membrane oxygenation (ECMO). Paired initial and follow-up samples were...

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PMID: 41062740
DOI: 10.1007/s15010-025-02650-5
PMCID: PMC12864348

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