Article
Dissecting Phenotype from Genotype with Clinical Isolates of SARS-CoV-2 First Wave Variants.
Viruses - 23 Feb 2023
Taylor Mariah K, Williams Evan P, Xue Yi, Jenjaroenpun Piroon, Wongsurawat Thidathip, Smith Amanda P, Smith Amber M, Parvathareddy Jyothi, Kong Ying, Vogel Peter, Cao Xueyuan, Reichard Walter, Spruill-Harrell Briana, Samarasinghe Amali E, Nookaew Intawat, Fitzpatrick Elizabeth A, Smith Micholas Dean, Aranha Michelle, Smith Jeremy C, Jonsson Colleen B
Abstract excerpt
The emergence and availability of closely related clinical isolates of SARS-CoV-2 offers a unique opportunity to identify novel nonsynonymous mutations that may impact phenotype. Global sequencing efforts show that SARS-CoV-2 variants have emerged and then been replaced since the beginning of the pandemic, yet we have limited information regarding the breadth of variant-specific host responses. Using primary cell...
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