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Article

The significance of recurrent de novo amino acid substitutions that emerged during chronic SARS-CoV-2 infection: an observational study.

EBioMedicine - 1 Sept 2024

Ip Jonathan Daniel, Chu Wing-Ming, Chan Wan-Mui, Chu Allen Wing-Ho, Leung Rhoda Cheuk-Ying, Peng Qi, Tam Anthony Raymond, Chan Brian Pui-Chun, Cai Jian-Piao, Yuen Kwok-Yung, Kok Kin-Hang, Shi Yi, Hung Ivan Fan-Ngai, To Kelvin Kai-Wang

Abstract excerpt

BACKGROUND: De novo amino acid substitutions (DNS) frequently emerge among immunocompromised patients with chronic SARS-CoV-2 infection. While previous studies have reported these DNS, their significance has not been systematically studied. METHODS: We performed a review of DNS that emerged during chronic SARS-CoV-2 infection. We searched PubMed until June 2023 using the keywords "(SARS-CoV-2 or COVID-19) and...

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Identifiers

PMID: 39146693
DOI: 10.1016/j.ebiom.2024.105273
PMCID: PMC11379563

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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