Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TMEM258 modulates immune infiltration networks underlying co-susceptibility to Crohn disease and acute pancreatitis.

Medicine - 3 Oct 2025

Lu Guijun, Zhou Shengyi, Shen Jiaxin, Chi Xintong, Wang Yuping, Zhang Xinyi, Wei Xujin, Liu Wenming

Abstract excerpt

Crohn disease (CD) is an immune-mediated chronic inflammatory disease of the gastrointestinal tract. In addition to common intestinal symptoms such as abdominal pain and diarrhea, it may be combined with extraintestinal manifestations in the joints, skin, and biliopancreatic tract. Previous studies have reported a causal association between inflammatory bowel disease and acute pancreatitis (AP), but the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Membrane Proteins

Share to Mendelian Randomization Analysis

Share to Pancreatitis

Share to Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41054129
DOI: 10.1097/MD.0000000000044807
PMCID: PMC12499840

Genes

TMEM258
CD28
DHX58
KLRG1
MARK3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TMEM258 modulates immune infiltration networks underlying co-susceptibility to Crohn disease and acute pancreatitis.PMID 41054129Read ↗

Improved integrative framework combining association data with gene expression features to prioritize Crohn's disease genes.Semantic proximity Read ↗

Key Disease-Related Genes and Immune Cell Infiltration Landscape in Inflammatory Bowel Disease: A Bioinformatics InvestigationSemantic proximity Read ↗

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.Semantic proximity Read ↗

Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes.Semantic proximity Read ↗

The IBD interactome: an integrated view of aetiology, pathogenesis and therapy.Semantic proximity Read ↗

Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants.Semantic proximity Read ↗

Evaluating the causal effect of circulating proteome on the risk of inflammatory bowel disease-related traits using Mendelian randomization.Semantic proximity Read ↗

Inflammatory Bowel Disease and Neurodegenerative Disorders: Integrated Evidence from Mendelian Randomization, Shared Genetic Architecture and TranscriptomicsSemantic proximity Read ↗

Integrating Mendelian randomization and multiple-trait colocalization to uncover cell-specific inflammatory drivers of autoimmune and atopic diseaseSemantic proximity Read ↗

A Convergent Study of Genetic Variants Associated With Crohn’s Disease: Evidence From GWAS, Gene Expression, Methylation, eQTL and TWASSemantic proximity Read ↗

Main genetic factors associated with inflammatory bowel diseases and their consequences on intestinal permeability: involvement in gut inflammation.Semantic proximity Read ↗

Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.