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Article

MLN4924 inhibits macrophage foam cell formation by enhancing autophagy and regulating metabolic phenotype.

Lipids in health and disease - 2 Oct 2025

Xing Lei, Bu Yu, Shi Jingqi, Liu Jing, Hu Fan, Zhang Minghua, Fan Jiao

Abstract excerpt

BACKGROUND: MLN4924 is a novel small molecule inhibitor of neddylation. During clinical trials, it has demonstrated promising therapeutic efficacy in hematological malignancies, lung cancer, and colon cancer. MLN4924 possesses anti-inflammatory properties and promotes cardiomyocyte autophagy. Given that atherosclerosis is an inflammatory disease in which autophagy and cellular senescence are key factors, we...

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Identifiers

PMID: 41039585
DOI: 10.1186/s12944-025-02683-7
PMCID: PMC12492866

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ABCA1
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CD36
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