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Article

SIRT6 reduces macrophage foam cell formation by inducing autophagy and cholesterol efflux under ox-LDL condition.

The FEBS journal - 1 May 2017

He Jiangping, Zhang Guangya, Pang Qi, Yu Cong, Xiong Jie, Zhu Jing, Chen Fengling

Abstract excerpt

SIRT6 is a pivotal regulator of lipid metabolism. It is also closely connected to cardiovascular diseases, which are the main cause of death in diabetic patients. We observed a decrease in the expression of SIRT6 and key autophagy effectors (ATG5, LC3B, and LAMP1) in ox-LDL-induced foam cells, a special form of lipid-laden macrophages. In these cells, SIRT6 WT but not SIRT6 H133Y overexpression markedly reduced...

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Share to ATP Binding Cassette Transporter 1
Share to ATP Binding Cassette Transporter, Subfamily G, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autophagy-Related Protein 5

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Share to Lipoproteins, LDL

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Source

Identifiers

PMID: 28296196
DOI: 10.1111/febs.14055

Genes

SIRT6
ATG5
ABCA1
ABCG1
LAMP1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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