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Molecular characterization of colistin resistance in carbapenem-resistant Klebsiella pneumoniae from a tertiary hospital in China.

Microbiology spectrum - 7 Oct 2025

Qi Saiqi, Li Haijun, Ma Jilei, Liu Cailin, Yi Nan, Sun Shijun, Wang Wanhai

Abstract excerpt

Colistin resistance in carbapenem-resistant Klebsiella pneumoniae (CRKP) poses a significant global health challenge, as colistin remains the last-resort antibiotic for treating multidrug-resistant K. pneumoniae infections. This study aimed to investigate the prevalence and molecular mechanisms underlying colistin resistance in CRKP (Colr-CRKP) isolates in Henan, China, from 2021 to 2024. The minimum inhibitory...

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PMID: 40879378
DOI: 10.1128/spectrum.01049-25
PMCID: PMC12502562

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