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Article

Identification of therapeutic targets for rheumatic heart valve disease based on systematic druggable genome wide Mendelian randomization.

Medicine - 26 Sept 2025

Shi Wei-Hua, Zhang Jing-Chang, Xie Zhi-Tao, Zheng Yi-Sheng

Abstract excerpt

Rheumatic heart valve disease (RHD) is a chronic immune valvular heart disease caused by rheumatic fever, primarily affecting the mitral and aortic valves. It often leads to atrial fibrillation, heart failure, and even premature death. Currently, there are no effective therapeutic drugs available, partially due to the lack of appropriate therapeutic targets. To identify therapeutic targets for RHD, we employed a...

Read the complete abstract on PubMed

Topics

Humans
Rheumatic Heart Disease
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
Heart Valve Diseases
Molecular Docking Simulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genome-Wide Association Study

Quantitative Trait Loci

Molecular Targeted Therapy

Source

Open in PubMed Open full text

Identifiers

PMID: 41029154
DOI: 10.1097/MD.0000000000044531
PMCID: PMC13592968

Genes

RHD
LILRB1
CA2
F13A1
FMO4
GRAMD1B
LPL
OXTR
PNP
TFRC
TUBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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