Exploring potential drug targets for SLE through Mendelian randomization and network pharmacology.

Abstract excerpt

BACKGROUND: Systemic lupus erythematosus (SLE) is a complex and incurable autoimmune disease, so several drug remission for SLE symptoms have been developed and used at present. However, treatment varies by patient and disease activity, and existing medications for SLE were far from satisfactory. Novel drug targets to be found for SLE therapy are still needed. METHODS: Mendelian randomization (MR), an...

Topics

• Humans
• Mendelian Randomization Analysis
• Lupus Erythematosus, Systemic
• Genome-Wide Association Study
• Molecular Docking Simulation
• Network Pharmacology