Identification of potential drug targets for rheumatoid arthritis from genetic insights: a Mendelian randomization study

Abstract excerpt

INTRODUCTION: Rheumatoid arthritis (RA) is a chronic inflammatory illness that mostly affects the joints of the hands and feet and can reduce life expectancy by an average of 3 to 10 years. Although tremendous progress has been achieved in the treatment of RA, a large minority of patients continue to respond poorly to existing medications, owing in part to a lack of appropriate therapeutic targets. METHODS: To...

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