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Article

Misfolding CPA1 mutation accelerates precancerous pancreas lesions in KC mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 Oct 2025

Demcsák Alexandra, Sahin-Tóth Miklós

Abstract excerpt

Germline mutations in the CPA1 gene encoding carboxypeptidase A1 were found in association with chronic pancreatitis and pancreatic ductal adenocarcinoma (PDAC). The mutations increase pancreatic disease risk, presumably, by causing proenzyme misfolding and endoplasmic reticulum stress. Previously, we showed that CPA1 N256K mice that carry the p.N256K misfolding human CPA1 mutation in the mouse Cpa1 gene develop...

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Share to Pancreatic Neoplasms
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Pancreas

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Source

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Identifiers

PMID: 40982355
DOI: 10.1152/ajpgi.00025.2025
PMCID: PMC12829554

Genes

CPA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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