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Article

Ethanol feeding accelerates pancreatitis progression in CPA1 N256K mutant mice.

American journal of physiology. Gastrointestinal and liver physiology - 1 Apr 2020

Orekhova Anna, Geisz Andrea, Sahin-Tóth Miklós

Abstract excerpt

Alcoholic pancreatitis is a multifactorial, progressive, inflammatory disorder of the pancreas. Alcohol initiates pancreatitis and promotes its progression in the context of genetic susceptibility and/or other environmental risk factors such as smoking. Genetic mutations can cause digestive enzyme misfolding, which induces endoplasmic reticulum (ER) stress and elicits pancreatitis. Here, we tested the hypothesis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32116022
DOI: 10.1152/ajpgi.00007.2020
PMCID: PMC7191466

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