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Article

Genetic risk in chronic pancreatitis: the misfolding-dependent pathway.

Current opinion in gastroenterology - 1 Sept 2017

Sahin-Tóth Miklós

Abstract excerpt

PURPOSE OF REVIEW: Genetic risk in chronic pancreatitis is partly due to mutations that cause misfolding of digestive enzymes and elicit endoplasmic reticulum stress. This review examines recent developments in this concept. RECENT FINDINGS: The best characterized misfolding variants in the highly expressed digestive proteases cationic trypsinogen (PRSS1) and carboxypeptidase A1 (CPA1) are strong, causative risk...

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Topics

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Share to Endoplasmic Reticulum Stress
Share to Enzyme Activation
Share to PRSS1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Pancreatitis, Chronic

Share to Pancreatitis Pathology and Treatment

Share to Protein Folding

Share to Trypsin

Source

Open in PubMed Open full text

Identifiers

PMID: 28650851
DOI: 10.1097/MOG.0000000000000380
PMCID: PMC5549634

Genes

CPA1
PRSS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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