Article

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimates

2020-06-02

Abstract excerpt

Variation in adiposity is associated with cardiometabolic disease outcomes, but the mechanisms leading from this exposure to disease are unclear. This study aimed to estimate effects of adiposity, proxied by body mass index (BMI), on 3,622 unique plasma proteins measured by the SomaLogic platform in 2,737 healthy participants from the INTERVAL study of UK blood donors. We conducted both observational and Mendelian...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 66a78376-455d-5eb2-9e50-5292c3a7b4aa
DOI: 10.1101/2020.06.01.20119081

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of adiposity on the human plasma proteome: Observational and Mendelian randomization estimatesDOI 10.1101/2020.06.01.20119081Read

Effects of adiposity on the human plasma proteome: observational and Mendelian randomisation estimatesSemantic proximity Read

Elucidating the genetic risk of obesity through the human blood plasma proteomeSemantic proximity Read

Revealing the role of the human blood plasma proteome in obesity using genetic driversSemantic proximity Read

Proteo-genomic analyses in relatively lean Chinese adults identify proteins and pathways that affect general and central adiposity levelsSemantic proximity Read

Associations of Adiposity, Circulating Protein Biomarkers, and Risk of Major Vascular DiseasesSemantic proximity Read

Phenome-wide Mendelian randomization identifying circulating proteins for cardiovascular traits in populations of African ancestrySemantic proximity Read

Clinical implications of bone marrow adiposity identified by phenome-wide association and Mendelian randomization in the UK Biobank.Semantic proximity Read

Systematic discovery of gene-environment interactions underlying the human plasma proteome in UK BiobankSemantic proximity Read

Metabolic Signatures of Adiposity in Young Adults: Mendelian Randomization Analysis and Effects of Weight ChangeSemantic proximity Read

Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank: A Mendelian Randomization Study.Semantic proximity Read

A Sex-specific Mendelian Randomization-Phenome-Wide Association Study of Body Mass IndexSemantic proximity Read

A data-driven approach for studying the role of body mass in multiple diseases: a phenome-wide registry-based case-control study in the UK Biobank.Semantic proximity Read