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Article

Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease.

Diabetes - 1 Aug 2021

Martin Susan, Cule Madeleine, Basty Nicolas, Tyrrell Jessica, Beaumont Robin N, Wood Andrew R, Frayling Timothy M, Sorokin Elena, Whitcher Brandon, Liu Yi, Bell Jimmy D, Thomas E Louise, Yaghootkar Hanieh

Abstract excerpt

To understand the causal role of adiposity and ectopic fat in type 2 diabetes and cardiometabolic diseases, we aimed to identify two clusters of adiposity genetic variants: one with "adverse" metabolic effects (UFA) and the other with, paradoxically, "favorable" metabolic effects (FA). We performed a multivariate genome-wide association study using body fat percentage and metabolic biomarkers from UK Biobank and...

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Source

Identifiers

PMID: 33980691
DOI: 10.2337/db21-0129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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